Neuron Activity and Tissue Oxygenation In The Brain
Single-Neuron Activity and Tissue Oxygenation
Based on a specific customer request, Unisense developed a combined microsensor for measuring oxygen tension and action potentials simultaneously. The sensor - called an APOX sensor - was first used in a study of the cerebral cortex where single neuron neural activity and oxygen consumption was investigated. The authors showed that neuron activity was accompagnied by decreased in tissue oxygenation and that this oxygenation can be used to predict "the orientation selectivity and ocular dominance of neighboring neurons" (Thompson et al 2005).
The APOX sensor consists of a Clark-type oxygen microsensor and a platinum electrode integrated into one sensor with a tip size of approximately 30 µm.