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Neuron Activity and Tissue Oxygenation In The Brain

Single-Neuron Activity and Tissue Oxygenation

Based on a specific customer request, Unisense developed a combined microsensor for measuring oxygen tension and action potentials simultaneously. The sensor - called an APOX sensor - was first used in a study of the cerebral cortex where single neuron neural activity and oxygen consumption was investigated. The authors showed that neuron activity was accompagnied by decreased in tissue oxygenation and that this oxygenation can be used to predict "the orientation selectivity and ocular dominance of neighboring neurons" (Thompson et al 2005).

The APOX sensor consists of a Clark-type oxygen microsensor and a platinum electrode integrated into one sensor with a tip size of approximately 30 ยตm.

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APOX sensor

Thompson,J.K. et al (2003), Single-Neuron Activity and Tissue Oxygenation in the Cerebral Cortex, Science, 1070 - 1072, vol. 299 Read abstract

Thompson,J.K. et al (2005), Separate spatial scales determine neural activity-dependent changes in tissue oxygen within central visual pathways, J Neurosci, 9046 - 9058, vol. 25 Read abstract

Mayhew,W. et al (2003), NEUROSCIENCE: A Measured Look at Neuronal Oxygen Consumption, Science, 1023 - 1024, vol. 299

Masamoto,K et al (2009), Brain Tissue Oxygen Consumption And Supply Induced By Neural Activation:, , 287 - 292, vol. Read abstract

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