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Brain Oxygen Measurements

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Brain oxygen measurement

Unisense can make oxygen microsensors with a tip size as small as 3-5 µm. This enables the insertion of the sensors into soft living tissue like the brain in vivo. For instance, Offenhauser et al. (2005) used small oxygen microsensors to study the coupling of neural activity and localized oxygen consumption in rat cerebral cortex tissue.

The authors found a relationship between the cerebral blood flow and the tissue oxygen tension, suggesting the presence of a tissue oxygen reserve.

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Oxygen Microsensor

Schneider, Justus et al (2017), Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus, Journal of Cerebral Blood Flow & Metabolism, 0271678X1774009 - , vol. Read abstract

Enager, Pia et al (2009), Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex, Journal of Cerebral Blood Flow and Metabolism, 976 - 986, vol. 29 Read abstract

Caesar, Kirsten et al (2008), Gamma-aminobutyric acid modulates local brain oxygen consumption and blood flow in rat cerebellar cortex, Journal of Cerebral Blood Flow and Metabolism, 906 - 915, vol. 28 Read abstract

Offenhauser, Nikolas et al (2005), Activity-induced tissue oxygenation changes in rat cerebellar cortex: Interplay of postsynaptic activation and blood flow, Journal of Physiology, 279 - 294, vol. 565 Read abstract

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