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Microsensors in Comparative Medicine Research

Oxygen Microprofiles in the Retina of Antarctic Icefish

With the Unisense microsensors and MicroProfiling System it is possible to make microprofiles with extreme positioning accuracy and high spatial resolution. The small tip size of the Unisense microsensors enables insertion of the tip into living tissue giving you the possibility to obtain real-time data directly in the animal.

Dr. Henrik Lauridsen from the Comparative Medicine Laboratory at the Department of Clinical Medicine, Aarhus University has used the Unisense oxygen microsensor with a tip size of 10 μm and 25 μm (OX-10 and OX-25) to make oxygen microprofiles in the retina of Antarctic icefish. 

 

From the oxygen microprofiles Dr. Lauridsen showed that the pre-retinal (PRV) oxygen level on the inside of the retina in the white-blooded Chaenocephalus aceratus icefish was high with a decreasing oxygen level towards the outer portion of the retina. This oxygen profile was inverted compared to the red-blooded Nototehnia coriiceps that had the highest oxygen con¬tent in the choroid rete mirabile (CRM) on the outside of the retina where oxygen is secreted from hemoglobin (Figure 2).

 

The white-blooded icefish has a high vascularization and increased blood supply on the inside of the retina compared to related red-blooded fish (con¬firmed with ultrasound). The results indicated that the oxygenation follows the high degree of vascularization in the icefish and that increased blood supply is a way of maintaining the oxygen supply in the retina of the icefish.


The study provides new insights about the vascularization and oxygen supply in the retina of icefish and hopefully these results can contribute to a better understanding of eye diseases like age related macular degenera¬tion and diabetic retinopathy which are both characterized by an increased vascularization in the eye.

 

 

Suggested Products
Sensors OX-10, OX-25, pH-25
Amplifier System Single or MultiChannel UniAmp
Positioning System MicroProfiling System
Software SensorTrace Suite (including Profiling software)

 

Oxygen Oxygen microprofiles in retina of icefish

Oxygen microprofiles in retina of icefish

See in the video how Dr. Henrik Lauridsen is recording oxygen microprofiles through the retina of an icefish.

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Ceja-Navarro, J.A. et al (2018), Gut anatomical development and microbial functional assembly enable lignocellulose deconstruction and colony subsistence of a wood-feeding beetle., Nature Microbiology, - , vol. in review

Persson, Patrik et al (2019), Acute intrarenal angiotensin (1-7) infusion decreases diabetes-induced glomerular hyperfiltration but increases kidney oxygen consumption in the rat, Acta Physiologica, e13254 - , vol.

Wang, Wenguang et al (2019), Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy, Nature Communications, 1 - 11, vol. 10 Read abstract

Lane, Steven J. et al (2018), Costs of epibionts on Antarctic sea spiders, Marine Biology, 1 - 8, vol. 165 Read abstract

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