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Biomedical implications of H2 enriched drinking water

Biomedical implications of H2 enriched drinking water

Drinking water enriched with dissolved hydrogen has been reported to have a positive effect on many healths and well being conditions. This has made a market, predominately in Japan, to commercialize H2-enriched water for health and body recovery processes.

Unisense hydrogen microsensors have been used to document the possible positive effect of H2-enriched drinking water as a biomedical treatment. In the study by Kamimura et al. (2011) they found that obese rats that received H2 water were less affected by oxidative stress in connection with obesity compared to rats that received normal water.

Using a needle type H2 microsensor, the H2 concentration was monitored in rat liver. The measurements showed that H2 was accumulated in liver of fed rats but not in fasted rats (Kamimura personal communication).

A correlation between glycogen concentration and accumulated H2 was found using a Unisense needle type microsensor. It was therefore speculated that the higher concentration of glycogen found in the liver of obese rats were the most likely reason for the H2 accumulation.

The study also showed that a fatty liver from the rats drinking H2 rich water contained less oxidative stress marker proteins and looked healthier compared to the fat rats, that did not receive H2 enriched water. Hydrogen’s anti-oxidative effect on the liver is speculated to explain the difference.

The Unisense hydrogen sensors have also been used to show the effect of hydrogen in the following biomedical applications:

• Hydrogen’s protective effect during lung damages induced by irradiation ( Terasaki et al., 2012).
• The protective role of hydrogen rich water on liver injuries (Sun et al. 2011).
• Hydrogen’s protective effect on the Retina (Obarazauo et al, 2010).
• Hydrogen prevents degranulation of mast cells (Itoh et al., 2009).
• Hydrogen from intestinal bacteria is protective during induced hepatitis (Kajiya et al. 2009)
• Inhalation of H2 gas reduces heart injuries during oxygen deficit (Hayashida et al. 2008).

Unisense H2 microsensors are used by manufacturer of commercial hydrogen enriched water to control and monitor the dissolved H2 concentration.

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Kamimura et al. (2011), Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FG21 and Stimulating Energy Metabolism in db/db Mice, Obesity, Vol. 19: 1396-1403.

Terasaki et al. (2012) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, Vol. 301: L415-L426.

Sun et al. (2011) The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, Vol. 54: 471-480.

Yamamoto et al. (2019) Hydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen concentration in rat.
Scientific Reports, Vol 9, Issue 1. 1255.

Terasaki et al. (2019) Molecular hydrogen attenuates gefitinib-induced exacerbation of naphtalene-evoked acute lung injury through a reduction in oxidative stress and inflammation, Laboratory Investigation.

Iketani et al. (2018) Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice, Scientific Reports, Vol 8, Issue 1, p. 1-11.

He et al. (2017), Image-Guided Hydrogen Gas Delivery for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles, ACS Applied Materials and Interfaces, Vol 9, Issue 25, p. 21190-21199.

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