APOX Sensor

APOX with single neuron

Measure action potential and oxygen concentration simultaneously

Based on a specific customer request, Unisense has developed a combined microsensor for measuring oxygen tension and action potentials simultaneously. This sensor type has been applied in a study on single neuron activity published in Science by Thompson et al. 2003

The Unisense APOX microsensor is a miniaturized Clark-type oxygen sensor combined with a platinum action potential microsensor. The sensor is designed for research within neurophysiology. The Unisense oxygen microsensor is a Clark-type oxygen sensor with an internal reference and a guard cathode. The action potential electrode consists of a platinum tip protruding through a glass coating.

With its minute tip size, excellent response time, and insignificant stirring sensitivity the APOX microsensor facilitates reliable and fast measurements with a high spatial resolution. The signal from the oxygen sensing part of the APOX sensor should be connected to a high-precision picoammeter. The action potential sensing part must be connected to an action potential meter and a reference electrode must be provided. In many set-ups, this reference consists of the metal support for the experimental subject.

The LEMO connector of the APOX sensor should be connected to a Unisense amplifier e.g. Microsensor Multimeter. The action potentia...
APOX microsensor tip.
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Oxygen Microsensor

Thompson,J.K. et al (2003), Single-Neuron Activity and Tissue Oxygenation in the Cerebral Cortex, Science, 1070 - 1072, vol. 299 Read abstract

Thompson,J.K. et al (2005), Separate spatial scales determine neural activity-dependent changes in tissue oxygen within central visual pathways, J Neurosci, 9046 - 9058, vol. 25 Read abstract

Mayhew,W. et al (2003), NEUROSCIENCE: A Measured Look at Neuronal Oxygen Consumption, Science, 1023 - 1024, vol. 299

Masamoto,K et al (2009), Brain Tissue Oxygen Consumption And Supply Induced By Neural Activation:, , 287 - 292, vol. Read abstract

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