Benefits of Hydrogen

Hydrogen has been shown to exhibit prominent effects on a number of oxidative stress-mediated diseases, inflammatory- and allergy diseases. Unisense hydrogen microsensors have been involved in a number studies investigating the potential therapeutic effect of hydrogen supplementation. 

H2measurements in liver tissue

Oxidativestress is considered a major contributor to the development of a number ofhepatic disorders. Sun et al investigated the effect of hydrogen-rich saline supplementationto mice with acute hepatic failure. H2 concentrations in liver and kidneytissues were measured using a Unisense H2-50 microsensor by inserting themicrosensor 300 um into the tissue. Data demonstrated a notable improvement inthe conditions of H2-treated mice compared with that of control mice.

Hydrogen accumulateswith glycogen in liver tissue

Another study of H2 antioxidation effects concerned the therapeutic potential of H2 on metabolic syndromes. In this study Unisense H2-needle sensors were inserted directly into the liver of fed or fasted rats that was given H2-enriched water.Based on the microsensor data the Kamimura et al. found a difference in how well thehydrogen was maintained in the fed and fasted liver. In both cases H2concentration peaked 5 min after H2-water administration. However, while the fed liver maintained considerable H2 amounts after 1 hour, the H2 levels in the fasted liver returned to basal levels after 25 min. This led the researchers to speculate that hydrogen can be accumulated and reserved in the liver with glycogen, suggesting that glycogen consumption accompanies H2 release. 

Nakao,A. et al (2010), Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndromeGÇöan open label pilot study, Journal of clinical biochemistry and nutrition, 140 - , vol. 46

Kamimura,N. et al (2011), Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice, Obesity, 1396 - 1403, vol. 19

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