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Biomedical implications of H2 enriched drinking water

Biomedical implications of H2 enriched drinking water

Drinking water enriched with dissolved hydrogen has been reported to have a positive effect on many healths and well being conditions. This has made a market, predominately in Japan, to commercialize H2-enriched water for health and body recovery processes.

Unisense hydrogen microsensors have been used to document the possible positive effect of H2-enriched drinking water as a biomedical treatment. In the study by Kamimura et al. (2011) they found that obese rats that received H2 water were less affected by oxidative stress in connection with obesity compared to rats that received normal water.

Using a needle type H2 microsensor, the H2 concentration was monitored in rat liver. The measurements showed that H2 was accumulated in liver of fed rats but not in fasted rats (Kamimura personal communication).

Figure 1. Hydrogen concentration measured in rat liver of a fed or overnight-fasted rat liver. 
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A correlation between glycogen concentration and accumulated H2 was found using a Unisense needle type microsensor. It was therefore speculated that the higher concentration of glycogen found in the liver of obese rats were the most likely reason for the H2 accumulation.

Figure 2. Hydrogen concentration in open tubes with water and glycogen respectively after bubbling with H2.
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The study also showed that a fatty liver from the rats drinking H2 rich water contained less oxidative stress marker proteins and looked healthier compared to the fat rats, that did not receive H2 enriched water. Hydrogen’s anti-oxidative effect on the liver is speculated to explain the difference.

The Unisense hydrogen sensors have also been used to show the effect of hydrogen in the following biomedical applications:


• Hydrogen’s protective effect during lung damages induced by irradiation ( Terasaki et al., 2012).
• The protective role of hydrogen rich water on liver injuries (Sun et al. 2011).
• Hydrogen’s protective effect on the Retina (Obarazauo et al, 2010).
• Hydrogen prevents degranulation of mast cells (Itoh et al., 2009).
• Hydrogen from intestinal bacteria is protective during induced hepatitis (Kajiya et al. 2009)
• Inhalation of H2 gas reduces heart injuries during oxygen deficit (Hayashida et al. 2008).

Unisense H2 microsensors are used by manufacturer of commercial hydrogen enriched water to control and monitor the dissolved H2 concentration.

Examples of commercial, available hydrogen enriched drinking water
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References


Kamimura et al. (2011), Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FG21 and Stimulating Energy Metabolism in db/db Mice, Obesity, Vol. 19: 1396-1403.


Terasaki et al. (2012) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol, Vol. 301: L415-L426.


Sun et al. (2011) The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, Vol. 54: 471-480.


Obarazawa et al. (2010) Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. IOVS, Vol. 51: 487-492


Itoh et al. (2009) Molecular hydrogen suppresses Fc?RI – mediated signal transduction and prevents degranulation of mast cells. Biochemical and Biophysical Research Communication, Vol 389: 651-656.


Kajiya et al. (2009) Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochemical and Biophysical Research Communication, Vol 386: 316-321.


Hayashida et al. (2008), Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochemical and Biophysical Research Communication, Vol 373: 30-35.

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